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Specifica publications, and Relevant prior publications from Specifica scientists.

Pandemic’s silver lining
Fortunato Ferrara, Sara D’Angelo, M. Frank Erasmus, André A. Teixeira, Camila Leal-Lopes, Laura P. Spector, Tom Pohl, Adeline Fanni, Simon Cocklin, Andrew R. M. Bradbury

2022 | mAbs

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Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs
Andre Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca Buonpane, Horacio Nastri, Andrew Bradbury

2022 | mAbs

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A pandemic-enabled comparison of discovery platforms demonstrates a naive antibody library can match the best immune-sourced antibodies
Fortunato Ferrara, M. Frank Erasmus, Sara D’Angelo, Camila Leal-Lopes, Andre A. Teixeira, Alok Choudhary, William Honnen, David Calianese, Deli Huang, Linghan Peng, James E. Voss, David Nemazee, Dennis R. Burton, Abraham Pinter, Andrew R.M. Bradbury

2022 | Nature Communications

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Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries
Andre A. Teixeira, M. Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker, Andrew R.M. Bradbury

2021 | mAbs

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Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera
Nileena Velappan, Devin Close, Li-Wei Hung, Leslie Naranjo, Colin Hemez, Natasha DeVore, Donna McCullough, Antonietta M. Lillo, Geoffrey S. Waldo, Andrew R.M. Bradbury

2021 | peds

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A single donor is sufficient to produce a highly functional in vitro antibody library
M. Frank Erasmus, Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, Andre Teixeira, Rebecca Buonpane, Shaun M. Stewart, Nastri G. Horacio, Andrew R.M. Bradbury

2021 | Communications Biology

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Selection and characterization of Fc epsilon R1 phospho-ITAM specific antibodies
Nileena Velappan, Avnika Mahajan, Leslie Naranjo, Prianka Velappan, Nasim Andrews, Nick Tiee, Subhendu Chakraborti, Colin Hemez, Tiziano Gaiotto, Bridget Wilson, Andrew Bradbury

2019 | MAbs: 1-13

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Recombinant antibodies against mycolactone
Leslie Naranjo, Fortunato Ferrara, Nicolas Blanchard, Caroline Demangel, Sara D’Angelo, M. Frank Erasmus, André Teixeira, Andrew Bradbury

2019 | Toxins (Basel) 11(6)

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Rapid purification of billions of circulating CD19+ cells directly from leukophoresis samples
Fortunato Ferrara, Martin Kolnik, Sara D’Angelo, M. Frank Erasmus, André Teixeira, Daniela Vorholt, Andrew Bradbury

2018 | N Biotechnol 46

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When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions
Andrew Bradbury, Nathan Trinklein, Holger Thie, Ian Wilkinson, Atul Tandon, Stephen Anderson, Catherine Bladen, Brittany Jones, Shelly Force Aldred, Marco Bestagno, Oscar Burrone, Jennifer Maynard, Fortunato Ferrara, James Trimmer, Janina Görnemann, Jacob Glanville, Philipp Wolf, Andre Frenzel, Julin Wong, Xin Yu Koh, Hui-Yan Eng, David Lane, Marie-Paule Lefrance, Mike Clark, Stefan Dübel

2018 | MAbs 10 1-19

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Selection of phage displayed accessible recombinant targeted antibodies (SPARTA): methodology and applications
Sara D’Angelo, Fernanda Staquicini, Fortunato Ferrara, Daniela Staquicini, Geetanjali Sharma, Christy Tarleton, Huynh Nguyen, Leslie Naranjo, Richard Sidan, Wadih Arap, Andrew Bradbury, Renata Pasqualini

2018 | JCI Insight 3(9)

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Many routes to an antibody heavy-chain CDR3: necessary, yet insufficient for specific binding
Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, M. Frank Erasmus, Peter Hraber, Andrew Bradbury

2018 | Frontiers in Immunology 9

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Selected Prior Publications

High-throughput screening of single-chain antibodies using multiplexed flow cytometry
J Ayriss, T Woods, P Pavlik, Andrew Bradbury

2007 | J Proteome Res 6

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Eliminating helper phage from phage display
L Chasteen, J Ayriss, P Pavlik, Andrew Bradbury

2006 | Nucleic acids research 34

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Using phage display to select antibodies recognizing post-translational modifications independently of sequence context
J W Kehoe

2006 | Mol Cell Proteomics 5

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Characterizing monoclonal antibody epitopes by filtered gene fragment phage display
R Di Niro

2005 | The Biochemical journal 388

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Recombinatorial cloning using heterologous lox sites
R W Siegel, N Velappan, P Pavlik, L Chasteen, Andrew Bradbury

2004 | Genome Res 14

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Selecting open reading frames from DNA
P Zacchi, D Sblattero, F Florian, R Marzari, Andrew Bradbury

2003 | Genome Research 13

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Antibodies in haystacks: how selection strategy influences the outcome of selection from molecular diversity libraries
J Lou

2001 | Journal of immunological methods 253

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Exploiting recombination in single bacteria to make large phage antibody libraries
D Sblattero, Andrew Bradbury

2000 | Nat Biotechnol 18

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